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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1984-11-14
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pubmed:abstractText |
The pattern of distribution of antigens cross-reacting with antibodies to human blood group antigens A and B and two precursor molecules was examined by immunofluorescence in the epidermis, oral mucosa and forestomach of rats and mice. Staining for blood group antigen A was negative. In all epithelia examined, blood group antigen B was present at the surface of basal and parabasal cells, and the H antigen at the surface of spinous cells. N-acetyllactosamine was present on the cell membranes in the upper spinous and granular cell layers of epidermis and forestomach epithelium and was not expressed in the oral epithelia except for a limited area in the dorsal tongue epithelium. Thus, the expression of antigen varies both regionally and, as earlier shown in human epithelium, with the stage of maturation of cells within a given epithelium. The observed sequence of expression of these antigens during maturation differs from that of human epithelia, but the present study provides a basis for further experimental studies of the role of cell surface antigens in epithelial homeostasis and maturation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0302-766X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
237
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6206949-ABO Blood-Group System,
pubmed-meshheading:6206949-Animals,
pubmed-meshheading:6206949-Antibodies, Monoclonal,
pubmed-meshheading:6206949-Antigens, Surface,
pubmed-meshheading:6206949-Carbohydrate Sequence,
pubmed-meshheading:6206949-Cell Differentiation,
pubmed-meshheading:6206949-Epithelium,
pubmed-meshheading:6206949-Epitopes,
pubmed-meshheading:6206949-Mice,
pubmed-meshheading:6206949-Rats,
pubmed-meshheading:6206949-Tissue Distribution
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pubmed:year |
1984
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pubmed:articleTitle |
The distribution of blood group antigens in rodent epithelia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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