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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0020205,
umls-concept:C0596988,
umls-concept:C1171362,
umls-concept:C1414081,
umls-concept:C1414085,
umls-concept:C1415941,
umls-concept:C1515670,
umls-concept:C1521991,
umls-concept:C2931688
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pubmed:issue |
16
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pubmed:dateCreated |
1984-10-3
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pubmed:abstractText |
Sequential immunoprecipitates show that H-2dm1 mutant cells express a hybrid "H-2D/L" antigen exhibiting determinants normally associated with two different gene products of the parental d haplotype-i.e., the H-2Dd and H-2Ld antigens. The hybrid H-2D/Ldm1 antigen appears to consist of a portion of the NH2-terminal extracellular half of the H-2Dd antigen "fused" to a portion of the COOH-terminal extracellular half of the H-2Ld antigen. This structure is inferred from the reactivity of dm1 antigens with cytotoxic T lymphocytes specific for H-2Ld determinants and with monoclonal antibodies specific for determinants in the structural domains of H-2Ld or H-2Dd. The H-2D/Ldm1 molecule apparently retains all of the third external domain (C2 or alpha 3) and part of the second external domain (C1 or alpha 2) of H-2Ld, but its first external domain (N or alpha 1) derives from H-2Dd. From these findings and from previous peptide mapping studies, we propose that the H-2D/Ldm1 antigen is the product of a hybrid gene that has resulted from an unequal crossover between the parental H-2Dd and H-2Ld genes, leaving the N exon and part of the C1 exon of the H-2Dd gene joined to the H-2Ld gene beginning somewhere within its C1 exon.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-358801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6152713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6162792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6168578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6175568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6184620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6185588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6188160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6195894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6286837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6300887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6302702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-632584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6424290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6571712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6604086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6606620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-68094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6828150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6952248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-6980826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-699038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-699045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7011174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7058332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7077082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7135466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7191868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7217662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7231522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206494-7295646
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5204-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6206494-Animals,
pubmed-meshheading:6206494-Antibodies, Monoclonal,
pubmed-meshheading:6206494-Cross Reactions,
pubmed-meshheading:6206494-Epitopes,
pubmed-meshheading:6206494-Genes,
pubmed-meshheading:6206494-H-2 Antigens,
pubmed-meshheading:6206494-Mice,
pubmed-meshheading:6206494-Mice, Inbred Strains,
pubmed-meshheading:6206494-Mutation,
pubmed-meshheading:6206494-Nucleic Acid Hybridization,
pubmed-meshheading:6206494-Peptide Fragments
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pubmed:year |
1984
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pubmed:articleTitle |
A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dm1 mutant.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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