Linked Life Data

6202979

Source:http://linkedlifedata.com/resource/pubmed/id/6202979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-7-19
pubmed:abstractText
To evaluate timolol's ability to antagonize the "slow response" in cardiac tissues, isolated canine cardiac Purkinje fibers were exposed to 0.25 mM barium chloride to induce membrane depolarization, spontaneous automaticity, and slow response action potentials. The effects of timolol on action potential parameters and the cycle length of spontaneous automaticity were tested at concentrations of 10, 100, and 500 micrograms/ml. Timolol significantly depressed the action potential and slowed automaticity only at 100 and 500 micrograms/ml but not at 10 micrograms/ml. Since verapamil and nifedipine have been reported to completely suppress activity in this model at concentrations of 0.2-2.0 micrograms/ml, we conclude that timolol has little direct slow response blocking potency.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
506-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Effects of timolol on action potential characteristics and automaticity in barium-depolarized canine cardiac Purkinje fibers.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't