Linked Life Data

6175999

Source:http://linkedlifedata.com/resource/pubmed/id/6175999

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-6-14
pubmed:abstractText
Four sublines of the chemically induced BALB/c tumour MCG4 have been obtained after serial intraperitoneal transplantation in syngeneic recipients and have been named MCG4-O, MCG4-A, MCG4-B and MCG4-C. The four subline have been typed for H-2 antigens in a complement dependent microradioassay with H-2 alloantisera defining H-2 specificities as well as with two syngeneic anti tumour sera: BALB/c anti MCG4-O and BALB/c anti MCG4-A. The results obtained showed a progressive loss of the foreign H-2 antigens detected in the primitive line, MCG4-O, with a simultaneous appearance of the appropriate H-2 antigens detected in MCG4-B and MCG4-C. Furthermore the immunogenic capacity of the sublines decrease progressively with the transplantation procedures, rendering MCG4-O and MCG4-A highly immunogenic and capable of producing isoantibodies while MCG4-B and MCG4-C are poorly immunogenic. The results could suggest that the primitive subline is heterogeneous mixture of (H-2d) are immunoselected by the transplantation procedures with rejection of the most immunogenic clones, which would express the foreign H-2 antigens.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0034-9402
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
429-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Changes in the expression of H-2 antigenic determinants in several sublines proceeding from the same tumor].
pubmed:publicationType
Journal Article, English Abstract