Linked Life Data

6173492

Source:http://linkedlifedata.com/resource/pubmed/id/6173492

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-4-12
pubmed:abstractText
The transitional cells at the surface of the urinary bladder secrete and bind to their surfaces 1 or more glycosaminoglycans whose presence prevents bacterial adherence to the mucosa. Because it is believed that adherence is prerequisite to infection, we did the current studies to determine whether the antiadherence effect of natural and synthetic glycosaminoglycans prevents infection. We exposed intact rabbit bladders, mucin deficient rabbit bladders, and rabbit bladders treated with sodium pentosanpolysulfate, a similar but synthetic substitute for the surface glycosaminoglycan(s), to bacteria in vivo. We measured infection rates 48 hours after exposure. The infection rate was significantly higher in mucin deficient bladders than in controls (p less than 0.02). There was no significant difference between infection rates in controls and infection rates in bladders treated with sodium pentosanpolysulfate. These results support our impression that a bladder with an intact mucin layer is better able to resist infection than is a mucin deficient bladder. The natural surface glycosaminoglycan(s) and the synthetic substitutes that reproduce their antiadherence effect appear to be protecting factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-5347
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Prevention of urinary tract infection by the exogenous glycosaminoglycan sodium pentosanpolysulfate.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't