| pubmed-article:6160873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C0026969 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C1166621 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:6160873 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:6160873 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:6160873 | pubmed:dateCreated | 1981-3-24 | lld:pubmed |
| pubmed-article:6160873 | pubmed:abstractText | Polypeptide composition and endogenous phosphorylation were investigated in the subfractions of rat brain myelin isolated by either discontinuous or continuous sucrose density gradient centrifugation of myelin. Similarly, a myelin-like membrane fraction (SN4) was also studied. Observations were made that strongly indicated the presence of a calcium-stimulated protein kinase in a highly purified myelin preparation and which exclusively phosphorylated myelin basic proteins of the membrane preparation. Adenosine cyclic 3',5'-phosphate (cAMP) stimulated kinase on the other hand was found to be considerably enriched in the myelin-like membrane fraction. Although this latter enzyme is also capable of phosphorylating the basic proteins, its effect was at least 5 times weaker compared to the calcium-stimulated myelin protein kinase. Within the gradient subfractions there appeared a close relation between the amount of basic proteins and their calcium-stimulated phosphorylation; a similar relationship, however, was not obtained in the case of cAMP-dependent phosphorylation of myelin basic proteins. The former (i.e., Ca2+-stimulated phosphorylation) was found to require a protein factor that functionally resembled calmodulin. The results thus raises an interesting possibility of the presence of calmodulin-like proteins and a calcium-stimulated protein kinase in adult myelin membrane from mammalian brain, both of which have been hitherto unrecognized constituents of myelin membranes. | lld:pubmed |
| pubmed-article:6160873 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6160873 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6160873 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6160873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6160873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6160873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6160873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6160873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6160873 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6160873 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:6160873 | pubmed:author | pubmed-author:SulakheP VPV | lld:pubmed |
| pubmed-article:6160873 | pubmed:author | pubmed-author:DauerD MDM | lld:pubmed |
| pubmed-article:6160873 | pubmed:author | pubmed-author:PetraliE HEH | lld:pubmed |
| pubmed-article:6160873 | pubmed:author | pubmed-author:ThiessenB JBJ | lld:pubmed |
| pubmed-article:6160873 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6160873 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:6160873 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:6160873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6160873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6160873 | pubmed:pagination | 5363-71 | lld:pubmed |
| pubmed-article:6160873 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:6160873 | pubmed:meshHeading | pubmed-meshheading:6160873-... | lld:pubmed |
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| pubmed-article:6160873 | pubmed:meshHeading | pubmed-meshheading:6160873-... | lld:pubmed |
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| pubmed-article:6160873 | pubmed:meshHeading | pubmed-meshheading:6160873-... | lld:pubmed |
| pubmed-article:6160873 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6160873 | pubmed:articleTitle | Calcium ion stimulated endogenous protein kinase catalyzed phosphorylation of basic proteins in myelin subfractions and myelin-like membrane fraction from rat brain. | lld:pubmed |
| pubmed-article:6160873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6160873 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6160873 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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