Linked Life Data

6139471

Source:http://linkedlifedata.com/resource/pubmed/id/6139471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1984-1-7
pubmed:abstractText
Rabbit corneas were excised and mounted in a chamber to determine the permeability characteristics of a group of beta-blocking agents which varied in octanol-water partitioning over a fourfold logarithmic range. From the permeability rate at steady state, permeability coefficients (pH 7.65) were determined. For each drug the distribution coefficient and pKa were measured, permitting the partition coefficients to be estimated. Various correlations were determined for the log permeability coefficient as a sum of log functions of the partition (or distribution) coefficient, molecular weight, and/or degree of ionization. The best fit, as judged by a high correlation coefficient (r = 0.9756) and lack of systematic deviation, was represented by: log PT = 0.623 log DC - 0.108(log DC)2 - 5.0268.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1266-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Corneal penetration behavior of beta-blocking agents I: Physiochemical factors.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't