Linked Life Data

6138261

Source:http://linkedlifedata.com/resource/pubmed/id/6138261

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1983-12-17
pubmed:abstractText
Several drugs, known to influence the action or formation of histamine and SRS-A, were examined for their abilities to alter antigen (ovalbumin)-induced contractions of guinea-pig isolated lung parenchymal strips. Cumulative dose-response effects of ovalbumin were obtained on paired parenchymal strips, one used as control and the other drug treated. When used alone, mepyramine, 10(-6) M, phenoxybenzamine, 3 x 10(-5) M and FPL55712, 10(-5) M, did not alter ovalbumin-induced contractions, 5,8,11,14-eicosatetraynoic acid (ETYA), 10(-4) M, produced a small (2.5-fold) rightward shift of the dose-response curves to ovalbumin and histamine. Indomethacin, 5 x 10(-6) M, produced a small increase in the maximum response to ovalbumin and a small (2-fold) rightward shift of the histamine dose-response curve. The effect of indomethacin on ovalbumin-induced contraction was not seen in the presence of phenoxybenzamine and may therefore be due to an increase in histamine release. Combination of indomethacin with FPL55712 or ETYA did not alter antigen-induced contractions. The effect of ETYA on the histamine dose-response curve was not seen in the presence of indomethacin. Combination of phenoxybenzamine with FPL55712 or ETYA caused a marked reduction of the maximum contractile response to ovalbumin. The effect of phenoxybenzamine and ETYA was not observed in the presence of indomethacin. The results suggest that the ability of ETYA to reduce antigen responses in the absence or presence of phenoxybenzamine as well as histamine-induced contraction is related to inhibition of contractile product(s) of cyclooxygenase metabolism of arachidonic acid.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-22
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Pharmacological alteration of antigen-induced contraction of lung parenchymal strips isolated from the actively sensitized guinea pig.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.