Linked Life Data

6134734

Source:http://linkedlifedata.com/resource/pubmed/id/6134734

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1983-8-26
pubmed:abstractText
The amino acid and nucleotide sequences have been aligned for five preprosomatostatins: two from catfish, two from anglerfish, and one from rat. The physical characteristics of the aligned residues as well as substitutions in the nucleotide sequences suggest considerable mutability in one of the catfish and anglerfish precursors while three of the preprohormones which give rise to somatostatins-14 are closely related. Although there is a considerable number of amino acid substitutions within the aligned somatostatin-14 precursors, there is a high degree of structural relatedness among them. These results suggest that additional physiological roles for the amino acid sequences outside of the hormone region are likely. The predicted secondary structures of the three somatostatin-14 precursors are dominated by helical and turn configurations which are correlated with observed co- and post-translational processing of the preprohormones.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
258
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8788-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Nucleotide and amino acid sequence comparisons of preprosomatostatins.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't