Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
1983-6-10
|
| pubmed:abstractText |
We assessed the electrophysiological properties of prenalterol, a new beta-selective agonist, in 10 patients with normal and 10 patients with delayed atrioventricular (A-V) conduction times. We evaluated sinus node function, A-V conduction times, refractory periods, atrial or ventricular arrhythmias, spontaneous or induced by the single extrastimulus technique during basal conditions, 5 minutes after a first dose of 20 micrograms/kg of prenalterol, and 5, 15 and 30 minutes after a second injection of the same dose. Prenalterol increased heart rate about 20%, with statistically significant shortening of right atrial refractory periods, A-V nodal functional and effective refractory periods and A-H interval in both groups after the first dose. In the 6 patients with sick sinus syndrome, prenalterol increased heart rate significantly and decreased maximum sinus node recovery time which reached a statistically significant value (P less than 0.05) 5 and 30 minutes after the second dose. At the highest dose, prenalterol seemed to increase the number of ventricular and/or atrial arrhythmias only in those patients with the arrhythmias before treatment. Prenalterol increases heart rate and decreases A-V node conduction times. The shortening of maximum sinus node recovery time in patients with the sick sinus syndrome, especially if confirmed after oral administration, could indicate a specific use of this drug in patients with sinus bradycardia or atrial fibrillation with a slow ventricular response.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0167-5273
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
391-400
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6132888-Adrenergic beta-Agonists,
pubmed-meshheading:6132888-Arrhythmias, Cardiac,
pubmed-meshheading:6132888-Atrioventricular Node,
pubmed-meshheading:6132888-Electrophysiology,
pubmed-meshheading:6132888-Heart Conduction System,
pubmed-meshheading:6132888-Humans,
pubmed-meshheading:6132888-Practolol,
pubmed-meshheading:6132888-Prenalterol,
pubmed-meshheading:6132888-Purkinje Fibers,
pubmed-meshheading:6132888-Sick Sinus Syndrome,
pubmed-meshheading:6132888-Sinoatrial Node
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Electrophysiologic properties of prenalterol.
|
| pubmed:publicationType |
Journal Article
|