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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
5
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|
pubmed:dateCreated |
1982-10-12
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|
pubmed:abstractText |
The effect of estrogen on the gastric acid secretion and H+-transporting enzymes, K+-ATPase and K+-phosphatase, were investigated in the rat. The maximum H+ secretory rate in response to 1 mM histamine was significantly reduced (P less than 0.05) in both the isolated gastric mucosa obtained from the rats treated with estradiol in vivo for 7 days and the mucosa directly incubated in vitro with estradiol. The inhibitory effect on the gastric enzyme activities in vitro showed a dose-dependent pattern of a noncompetitive type. The result suggested that estradiol may have a direct action on the gastric H+ secretion by inhibiting the H+ transport enzyme activities.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-4212
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
60
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
680-4
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pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:6125253-Adenosine Triphosphatases,
pubmed-meshheading:6125253-Alkaline Phosphatase,
pubmed-meshheading:6125253-Animals,
pubmed-meshheading:6125253-Cation Transport Proteins,
pubmed-meshheading:6125253-Estradiol,
pubmed-meshheading:6125253-Female,
pubmed-meshheading:6125253-Gastric Acid,
pubmed-meshheading:6125253-Kinetics,
pubmed-meshheading:6125253-Rats,
pubmed-meshheading:6125253-Rats, Inbred Strains
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|
pubmed:year |
1982
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|
pubmed:articleTitle |
Inhibition of gastric H+ secretion, K+-ATPase and K+-phosphatase by estradiol in vivo and in vitro.
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|
pubmed:publicationType |
Journal Article,
In Vitro
|
