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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1982-6-21
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pubmed:abstractText |
1 Noradrenaline and Sgd 101/75 (4(2-imidazoline-amino)-2-methylindazol-chlorhydrate) acted as full agonists in contracting the rat anococcygeus. 2 Very low concentrations of phenoxybenzamine (0.3 nM for 2-30 min) reduced preferentially the effects of Sgd 101/75. Preparations made insensitive to Sgd 101/75 by phenoxybenzamine still contracted to noradrenaline, this contraction occurring in the presence of high concentrations (400 microM) of Sgd 101/75. 3 It is concluded therefore that the alpha 1-adrenoceptor in this preparation is not a homogeneous entity and must be subdivided into at least two subtypes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
549-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6121597-Adrenergic alpha-Agonists,
pubmed-meshheading:6121597-Animals,
pubmed-meshheading:6121597-Clonidine,
pubmed-meshheading:6121597-Muscle, Smooth,
pubmed-meshheading:6121597-Muscle Contraction,
pubmed-meshheading:6121597-Norepinephrine,
pubmed-meshheading:6121597-Phenoxybenzamine,
pubmed-meshheading:6121597-Rats,
pubmed-meshheading:6121597-Rats, Inbred Strains,
pubmed-meshheading:6121597-Receptors, Adrenergic,
pubmed-meshheading:6121597-Receptors, Adrenergic, alpha
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pubmed:year |
1982
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pubmed:articleTitle |
The existence of a new subtype of alpha-adrenoceptor on the rat anococcygeus is revealed by SGD 101/75 and phenoxybenzamine.
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pubmed:publicationType |
Journal Article,
In Vitro
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