Linked Life Data

6102949

Source:http://linkedlifedata.com/resource/pubmed/id/6102949

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-7-12
pubmed:abstractText
The effect of somatostatin on ion transport in the rabbit ileum was determined. Somatostatin (a) decreased that short circuit current (Isc) (-1.0 +/- 0.2 mueq/hr . cm2) and potential difference (PD), (b) increased net Na and Cl absorption (+1.5 +/- 0.3 and +2.4 +/- 0.4 mueq/hr . cm2, respectively), and (c) increased tissue conductance (+5.1 +/- 1.3 mmhos/cm2). The increase in net Na and Cl absorption was primarily due to an increase in mucosal-to-serosal movement of these ions. Somatostatin had no effect on 3-0-methyl-glucose absorption, nor the increase in Isc produced by either 3-0-methyl-glucose or glucose. Phentolamine did not reverse the decrease in Isc produced by somatostatin and catecholamine depletion with reserpine or 6-OH-dopamine did not inhibit the somatostatin-induced decrease in Isc. The cholinergic agonists, carbachol and bethanechol, and no effect on somatostatin-induced decrease in Isc and atropine neither affected Isc nor blocked the effect of somatastatin on Isc. These studies demonstrate that somatostatin increased both Na Na and Cl absorption across rabbit ileal mucosa and suggest that these effects do not involve adrenergic or cholinergic agonists. Somatostatin may have a direct effect on the enterocyte.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1559-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Somatostatin stimulates sodium and chloride absorption in the rabbit ileum.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.