Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1985-5-15
|
pubmed:databankReference | |
pubmed:abstractText |
We have determined the sequence of an 812-bp BamHI-EcoRI restriction fragment containing the 5' region of the human gene for PGK (3-phosphoglycerate kinase or ATP:3-phospho-D-glycerate 1-phosphotransferase; EC 2.7.2.3). The fragment contains 450 bp 5' to three start points for transcription (located by primer extension and S1 nuclease mapping), a leader sequence 85-94 bp long, the first exon of gene (65 bp), and part of the first intron. The promoter region is extremely G + C-rich, lacks a TATA box, and has an 8-bp direct repeat. A comparison of the promoter region for PGK with other promoters on the X-chromosome reveals homology with the promoter for HPRT, but not with the operator for factor IX.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0378-1119
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
32
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
409-17
|
pubmed:dateRevised |
2011-8-31
|
pubmed:meshHeading |
pubmed-meshheading:6099325-Base Sequence,
pubmed-meshheading:6099325-Cloning, Molecular,
pubmed-meshheading:6099325-DNA Restriction Enzymes,
pubmed-meshheading:6099325-Factor IX,
pubmed-meshheading:6099325-Female,
pubmed-meshheading:6099325-Gene Expression Regulation,
pubmed-meshheading:6099325-Humans,
pubmed-meshheading:6099325-Hypoxanthine Phosphoribosyltransferase,
pubmed-meshheading:6099325-Molecular Sequence Data,
pubmed-meshheading:6099325-Phosphoglycerate Kinase,
pubmed-meshheading:6099325-Promoter Regions, Genetic,
pubmed-meshheading:6099325-Transcription, Genetic,
pubmed-meshheading:6099325-X Chromosome
|
pubmed:year |
1984
|
pubmed:articleTitle |
Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|