Linked Life Data

609115

Source:http://linkedlifedata.com/resource/pubmed/id/609115

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1978-5-8
pubmed:abstractText
Mice of strain G which have Fv-4rr genotype resemble those with Fv-2rr genotype in resisting the induction of spleen foci or splenomegaly by Friend leukemia virus. However, NB-tropic Friend virus replicates well in Fv-2rr mice, but not in G mice. To determine the Fv-2 genotype, G mice were crossed with Fv-2rr mice, and the hybrids were tested for the susceptibility to NB-tropic Friend virus. The (G X Fv-2rr) F1 hybrids were similar to G. In F1 X Fv-2rr backcross generation, three types of mice appeared; 1) G type, 2) Fv-2rr type and 3) Fv-2ss type. Mice of the last type supported virus replication and developed splenomegaly. Mice of types 1), 2) and 3) appeared with the expected ratio of 2:1:1. It will be concluded that in G mice Fv-4r gene suppresses the virus replication, and hence masks the expression of Fv-2s gene. Data of F2 generation support this conclusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-5031
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
515-21
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Genetic resistance to Friend leukemia virus in mice: masking of Fv-2 phenotype by an epistatic gene, Fv-4.
pubmed:publicationType
Journal Article