Linked Life Data

5948192

Source:http://linkedlifedata.com/resource/pubmed/id/5948192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1966-4-9
pubmed:abstractText
Oh, J. O. (University of British Columbia, Vancouver, B.C., Canada), and E. J. Gill. Role of interferon-like viral inhibitor in endotoxin-induced corneal resistance to Newcastle disease virus. J. Bacteriol. 91:251-256. 1966.-A state of marked resistance to the toxic corneal effects of Newcastle disease virus (NDV) was observed in rabbit eyes after intravenous injection of 10 or 100 mug of typhoid endotoxin. By use of tissue cultures of rabbit corneal endothelial cells for assay, high titers of an interferon-like viral inhibitor were detected in serum and in ocular aqueous humor of these animals. The pretreatment of eyes with aqueous humor or serum containing the inhibitor markedly suppressed the production of corneal toxicity by NDV. The intravenous injection of 1 mug of the endotoxin had a negligible effect on the corneal reaction, and little or no inhibitor was found in either serum or aqueous humor. Normal aqueous humor or serum contained no inhibitor and had no suppressive effect on the NDV-induced reactions. The results indicated that the inhibitor played an important role in the induction of corneal resistance to NDV in vivo. The inhibitor in aqueous humor of endotoxin-injected rabbits was found to be derived from blood after an increase in the permeability of "blood-aqueous barrier" of iris due to the endotoxin. Therefore, intravenously administered typhoid endotoxin induced corneal resistance to NDV in rabbits through its dual action on host: (i) release of an interferon-like viral inhibitor into the blood stream and (ii) disruption of the blood-aqueous barrier of the iris, thus allowing the passage of the viral inhibitor from blood into the anterior chamber, where it modified the corneal endothelial cells to render them resistant to NDV.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13453519, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13559397, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13607918, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13622733, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13665017, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13699646, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13850016, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-13850230, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14208574, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14236314, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14256745, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14283274, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14404614, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14428440, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14478977, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14481337, http://linkedlifedata.com/resource/pubmed/commentcorrection/5948192-14797769
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1966
pubmed:articleTitle
Role of interferon-like viral inhibitor in endotoxin-induced corneal resistance to Newcastle disease virus.
pubmed:publicationType
Journal Article, In Vitro