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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1978-12-27
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pubmed:abstractText |
Experimentally induced brain glioma cell lines were studied in cell cultures for their fibrinolytic activity; simultaneously the mitotic index was determined. It was found that the most intense fibrinolytic activity of glioma cells coincides with mitotic waves. After 68 hr incubation of SD/G1 cells on a [125I]fibrin layer, [125I]fibrin digestion products were examined by gel chromatography. Hydroxy-urea and actinomycin D were used as inhibitors in cell cultures, investigating their effect on the expression of fibrinolysis. These studies reveal that [125I]fibrin digestion products are mainly low molecular weight (less than 12,000 daltons) compounds and that fibrinolysis is partially inhibited by the drugs added.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-510X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:568167-Animals,
pubmed-meshheading:568167-Astrocytoma,
pubmed-meshheading:568167-Cell Line,
pubmed-meshheading:568167-Dactinomycin,
pubmed-meshheading:568167-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:568167-Fibrinolysis,
pubmed-meshheading:568167-Glioma,
pubmed-meshheading:568167-Hydroxyurea,
pubmed-meshheading:568167-Mitotic Index,
pubmed-meshheading:568167-Neoplasms, Experimental,
pubmed-meshheading:568167-Plasminogen Activators,
pubmed-meshheading:568167-Rats,
pubmed-meshheading:568167-S100 Proteins
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pubmed:year |
1978
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pubmed:articleTitle |
Fibrinolysis induced by rat glioma cells. A mitosis-triggered process?
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pubmed:publicationType |
Journal Article,
Comparative Study
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