| pubmed-article:554860 | pubmed:abstractText | The purpose of this study was to determine the effects of sulfuric acid (H2SO4) alone and with ozone (O3) on rats. To accomplish this, rats were exposed for 8 hours daily to an atmosphere containing either nebulized H2SO4, H2SO4 plus 0.9 ppm O3, or 0.9 ppm O3. The atmosphere in the exposure chambers was maintained at a fairly constant temperature and humidity. Nebulized H2SO4 was delivered uniformly to provide a particle size of about 0.3 micron mass median diameter (MMD) and a mass concentration of 2 mg/m3. In preliminary experiments, animals exposed to 2 mg/m3 of H2SO4 daily for 82 days showed very slight morphologic injury to the respiratory tract. In contrast, biological effects were readily demonstrable in rats exposed to H2SO4 plus O3 or to O3 alone, possibly with some enhancement of effect in animals exposed to the mixture. The effects observed were characteristic of the response to O3 alone. | lld:pubmed |
