Linked Life Data

521742

Source:http://linkedlifedata.com/resource/pubmed/id/521742

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1980-3-17
pubmed:abstractText
Mouse embryos which are homozygous for the c25H deletion at the albino locus are developmentally arrested at the 2- to 6-cell cleavage stages. This study reveals that the mutant embryos cease development before they can be distinguished ultrastructurally from their normal litter-mates. After prolonged developmental delay (24--48 h), the nuclei of the mutant embryos become extremely aberrant in shape, whereas other subcellular organelles remain normal and there are no signs of pyknosis. Eventually, the mutant embryos do become pyknotic and begin to degenerate. The striking effects of this deletion on nuclear ultrastructure of cleavage-stage embryos are discussed in relation to biochemical and ultrastructural defects caused by other lethal deletions at the albino locus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-0752
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-11
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Ultrastructural studies of lethal c25H/C25H mouse embryos.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.