Linked Life Data

46804

Source:http://linkedlifedata.com/resource/pubmed/id/46804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-5-27
pubmed:abstractText
Spontaneous and evoked cortical electrical activity of the post-central gyrus was studied in 5 unparalyzed, unanesthetized monkeys during slow-wave sleep (SWS) and wakefulness (W), before and after the administration of a muscarinic anticholinergic agents, hyoscine. It was found that hyoscine reproduces the effect of SWS: (1) on spontaneous EEG activity and single unit discharges of the somatosensory cortes without any concomitant behavioral sleep; and (2) on surface evoked potentials and reactivity of cortical neurons to peripheral electrical stimulation. Short episodes of EEG desynchronization were noted in the alert state after hyoscine suggesting the existence of a phasic activating system unblocked by hyoscine. These observations support the concept of an EEG-behavior dissociation produced by muscarinic anticholinergic agents and extend this concept to single neuron activity. These observations also lead to the conclusion that tonic EEG activation during arousal may be cholinergic at the cortical level even though other neurotransmitters may be involved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-72
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Cholinergic mechanisms involved in cortical activation during arousal.
pubmed:publicationType
Journal Article