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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1975-2-27
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pubmed:abstractText |
1. The electrogenic contribution of the Na(+)-K(+) exchange pump to the membrane potential of the Anisodoris giant neurone (G cell) was examined under steady-state and Na(+) loaded conditions.2. The membrane potential was variable for the first 1-4 hr after impalement, but, in the absence of experimental manipulation, remained constant thereafter. The average membrane potential for ten cells maintained at 11-13 degrees C and measured 5-36 hr after impalement was 55.8 +/- 1.0 mV (S.E. of mean).3. Low concentrations of external ACh caused a reversible increase in membrane Na(+) conductance. Brief exposure to ACh proved a fast and reversible technique to load the cell with Na(+) ions, and transiently stimulate the electrogenic Na(+) pump.4. In ten cells maintained from 5 to 36 hr at 11-13 degrees C the reduction in membrane potential produced by inhibition of the Na(+) pump with ouabain was remarkably constant between cells and averaged + 9.7 mV.5. Cells maintained under steady-state conditions (at 11-13 degrees C) for extended periods of time were shown to be relatively insensitive to changes in temperature and to small changes in external K(+).6. It is estimated that the Na(+)-K(+) exchange pump contributes approximately - 10 mV to the steady-state resting potential of the G cell, and that two Na(+) ions are extruded for every K(+) ion transported into the cell per pump cycle.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-13320339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-14060441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-16749106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-4228075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-4344877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-4436828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-4555514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-4644325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-4646584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5039286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5133949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5133950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5487174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5501490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5501491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5780556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5822154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-5966435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-6034753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4436827-6035554
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
242
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-48
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4436827-Acetylcholine,
pubmed-meshheading:4436827-Animals,
pubmed-meshheading:4436827-Biological Transport, Active,
pubmed-meshheading:4436827-Culture Media,
pubmed-meshheading:4436827-Membrane Potentials,
pubmed-meshheading:4436827-Mollusca,
pubmed-meshheading:4436827-Neurons,
pubmed-meshheading:4436827-Ouabain,
pubmed-meshheading:4436827-Potassium,
pubmed-meshheading:4436827-Sodium,
pubmed-meshheading:4436827-Temperature
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pubmed:year |
1974
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pubmed:articleTitle |
Steady-state contribution of the sodium pump to the resting potential of a molluscan neurone.
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pubmed:publicationType |
Journal Article,
In Vitro
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