Linked Life Data

4083302

Source:http://linkedlifedata.com/resource/pubmed/id/4083302

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6A
pubmed:dateCreated
1986-1-30
pubmed:abstractText
Sixteen adults who had chronic asthma with nocturnal symptoms were selected to evaluate and compare the effectiveness of 7 A.M. versus 7 P.M. single daily dosing with the 24-hour sustained-release theophylline Uniphyl. The study was a randomized, double-blind, placebo-controlled trial in which the patients were given 800 mg of Uniphyl at either 7 A.M. or 7 P.M. for one week each. Serum theophylline levels showed significantly higher peak (18.1 +/- 1.8 micrograms/ml versus 12.7 +/- 1.2 microgram/ml) and trough (12.4 +/- 1.3 microgram/ml versus 7.6 +/- 1.0 microgram/ml) concentrations during evening dosing. Furthermore, daily peak flow values were higher in the morning when Uniphyl was given at 7 P.M. Thus, nocturnal dosing with Uniphyl gives higher serum theophylline concentrations and, with this, better control of nocturnal asthma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9343
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
62-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Comparison of morning and evening dosing with a 24-hour sustained-release theophylline, Uniphyl, for nocturnal asthma.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial