Linked Life Data

4070078

Source:http://linkedlifedata.com/resource/pubmed/id/4070078

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-1-9
pubmed:abstractText
The effects of apomorphine, lisuride and 9, 10 transdihydrolisuride (TDHL) were compared on two models of rotating rat. In rats with 6-hydroxydopamine (6OHDA) induced unilateral lesions, all three drugs evoked contralateral rotation. By contrast, in rats with unilateral electrolytical lesions of the striatum, only apomorphine and lisuride acted as agonists. TDHL did not cause any circling and inhibited rotation induced by apomorphine and lisuride. In other experiments the effects on body temperature was examined. All three drugs lowered the rectal temperature in normal mice; however, only apomorphine and--to some extent--lisuride reversed the hypothermia induced by reserpine. Both lisuride and TDHL inhibited the hypothermia reversal induced by apomorphine. The presented results are interpreted in terms of lower intrinsic activities of TDHL and lisuride in comparison with apomorphine. The lower intrinsic activity is manifested as partial agonist or antagonist type of action in dependence on the location and the state of receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0244
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Lisuride and transdihydrolisuride: differences in action on central dopaminergic functions in dependence on the location and the state of receptors.
pubmed:publicationType
Journal Article, Comparative Study