Linked Life Data

4068200

Source:http://linkedlifedata.com/resource/pubmed/id/4068200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1986-1-21
pubmed:abstractText
To clarify the peripheral origin of plasma dopamine (DA), we studied the changes in plasma levels of free and conjugated catecholamines after nephrectomy, adrenalectomy, chemical sympathectomy and renal denervation. Nephrectomy markedly increased conjugated DA levels, indicating that plasma DA is rapidly excreted through the kidney and originates outside the kidney. Adrenalectomy reduced plasma total epinephrine (E) to undetectable limits, whereas total norepinephrine (NE) and DA levels remained unchanged. In addition, the subsequent immobilization stress significantly increased both total NE and DA, but not E. Chemical sympathectomy with 6-hydroxydopamine decreased both NE and DA by 66% and 72%, respectively. E level, however, was not affected by sympathectomy. Although the following immobilization stress significantly increased all catecholamines levels, the magnitude of increase in concentrations of NE and DA were much less than that of E. These results suggest that plasma DA is mainly derived from the peripheral sympathetic nerve terminals. However, the renal nerve, one of the sympathetic nerves, did not serve as a source of plasma DA because renal denervation had no effect on plasma DA levels in spite of the marked depletion of free DA in the kidney.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0047-1828
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
1028-34
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Peripheral origin of plasma dopamine.
pubmed:publicationType
Journal Article