Linked Life Data

4066024

Source:http://linkedlifedata.com/resource/pubmed/id/4066024

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-1-22
pubmed:abstractText
We synthesized an octapeptide, H-Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly-OH, and a hexadecapeptide, H-Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly-Lys-Asn-Gly-Ser-Gln-Met-Arg-Leu-OH, which corresponded to amino acids 61 to 68 and 61 to 76, respectively, of the amino acid sequence of a crystalline protein reported to be tuberculin active. Authenticity and purity of the synthesized peptides were confirmed by high-pressure liquid chromatography, amino acid analysis, mass spectrometry, and protein sequencer analysis. Tuberculin activity of the synthesized peptides was examined in guinea pigs sensitized with Mycobacterium tuberculosis or Mycobacterium bovis BCG and in tuberculin-positive healthy humans. Neither the octa- nor the hexadecapeptide was as active as tuberculin skin-test antigen.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
614-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Lack of tuberculin activity of synthetic peptides.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.