Linked Life Data

4046070

Source:http://linkedlifedata.com/resource/pubmed/id/4046070

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-11-4
pubmed:abstractText
The interaction of formaldehyde (CH2O) with reduced glutathione (GSH) was evaluated in aqueous solution and in isolated perfused lungs and livers. Addition of CH2O (0-4.9 mM) to a solution of 0.17 mM GSH in 2 mM EDTA, pH 7.4, resulted in a time- and concentration-dependent depletion of GSH. Perfusion of livers with fortified Krebs-Ringer bicarbonate buffer containing 0.3-4.9 mM CH2O resulted in a dose-dependent depletion of GSH. Perfusion of isolated ventilated lungs with perfusate containing 4.9 mM CH2O resulted in a depletion of GSH to 75% of controls. However, lower concentrations of CH2O in the lung perfusate did not result in depletion of GSH. These results demonstrate that exposure to CH2O in aqueous solution or in the perfused lung and liver is capable of depleting endogenous GSH. However, the concentrations of CH2O required to yield a significant depletion of endogenous GSH exceed those encountered in vivo. Thus, it is unlikely that depletion of GSH by CH2O is a causal factor in formaldehyde-induced toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-4108
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Interaction of formaldehyde with glutathione in the isolated/ventilated perfused lung and the isolated perfused liver.
pubmed:publicationType
Journal Article, In Vitro