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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1985-9-19
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pubmed:abstractText |
A case of desmethylimipramine (DMI) overdose is described. The analysis of DMI and its main metabolite, 2-hydroxydesmethylimipramine (2-OH-DMI), in plasma was performed by high performance liquid chromatography with fluorescence detection. Characterization of the elimination kinetics of DMI by using the SAAM 25 computer program indicated Michaelis-Menten kinetics. The patient was phenotyped with respect to debrisoquine hydroxylation and classified as a slow hydroxylator. Both nonlinear kinetics and slow hydroxylation might have contributed to the marked difference between the concentration of DMI and 2-OH-DMI in plasma in this patient.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0163-4356
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
239-41
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading | |
pubmed:year |
1985
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pubmed:articleTitle |
Desmethylimipramine overdose: nonlinear kinetics in a slow hydroxylator.
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|