|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1985-8-15
|
|
pubmed:abstractText |
Pretreatment of adult male rats with sulmazole (AR-L 115 BS) results in a 2-6-fold increase of the liver microsomal scoparone O-demethylation and 7-ethoxycoumarin O-deethylation activity. The change in the ratio of the demethylation products scopoletin to isoscopoletin from 1 : 1.8 +/- 0.1 in control microsomes to 1: 2.5 +/- 0.1 in microsomes from sulmazole pretreated rats is statistically significant. Sulmazole produces a modified type II difference spectrum when added to microsomes of control or sulmazole-pretreated rats. Immunoquantitation of seven cytochromes P-450 showed that two forms, namely P-450 beta NF/ISF-G and P-450 beta NF-B, are increased 3-4-fold in the microsomes of sulmazole-pretreated rats.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0004-4172
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
698-703
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:4015736-Animals,
pubmed-meshheading:4015736-Cardiotonic Agents,
pubmed-meshheading:4015736-Cytochrome P-450 Enzyme System,
pubmed-meshheading:4015736-Enzyme Activation,
pubmed-meshheading:4015736-Enzyme Induction,
pubmed-meshheading:4015736-Imidazoles,
pubmed-meshheading:4015736-Immunoelectrophoresis,
pubmed-meshheading:4015736-Isoenzymes,
pubmed-meshheading:4015736-Kinetics,
pubmed-meshheading:4015736-Male,
pubmed-meshheading:4015736-Microsomes, Liver,
pubmed-meshheading:4015736-Mixed Function Oxygenases,
pubmed-meshheading:4015736-Rats,
pubmed-meshheading:4015736-Rats, Inbred Strains,
pubmed-meshheading:4015736-Scopoletin
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Induction of cytochrome P-450 isozymes in liver microsomes of rats treated with the cardiotonic agent sulmazole.
|
|
pubmed:publicationType |
Journal Article
|
