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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-6-18
|
| pubmed:abstractText |
The positive inotropic effect of AP-A was studied in anesthetized dogs with a severe stenosis of the left anterior descending coronary artery. Peak positive dP/dt (mm Hg/s) and % segment shortening (%SS) were used as indices of contractile function. AP-A (1.5-5.0 micrograms/kg, i.v.) produced positive inotropic effects globally (dP/dt, 1700 +/- 100 to 2650 +/- 250 mm Hg/s) and locally in the ischemic zone (%SS, 6.7 +/- 1.7 to 13.7 +/- 1.5%) without changing heart rate, mean arterial pressure or myocardial blood flow. These data suggest that AP-A may be potentially useful in the management of heart failure.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
271-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3987818-Animals,
pubmed-meshheading:3987818-Blood Pressure,
pubmed-meshheading:3987818-Cardiotonic Agents,
pubmed-meshheading:3987818-Coronary Circulation,
pubmed-meshheading:3987818-Coronary Disease,
pubmed-meshheading:3987818-Dogs,
pubmed-meshheading:3987818-Female,
pubmed-meshheading:3987818-Heart Rate,
pubmed-meshheading:3987818-Male,
pubmed-meshheading:3987818-Myocardial Contraction,
pubmed-meshheading:3987818-Peptides
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|