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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1985-4-19
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pubmed:abstractText |
We measured the serum concentration of alpha 1-acid glycoprotein (alpha 1-AGP) and we evaluated the content of its hepatic mRNA in rats after 17 alpha-ethynyloestradiol treatment or after turpentine-induced acute inflammation, or after both treatments performed simultaneously. We have also studied the affinity of serum alpha 1-AGP for concanavalin A under these conditions. Both types of stimuli induce a marked retention of the glycoprotein on free concanavalin A. The serum concentration of alpha 1-AGP is increased about 14-fold compared with that in control rats when a single pharmacological dose (50 micrograms) or multiple injections of 17 alpha-ethynyloestradiol are administered. This increase is greater in turpentine-oil-injected rats (about 21-fold) and reaches a maximum (about 32-fold) in rats injected with 17 alpha-ethynyloestradiol plus turpentine oil; this increase in alpha 1-AGP corresponds to the addition of the effects of the two inducing agents. Similar changes are also observed either in the alpha 1-AGP mRNA content as estimated by using an alpha 1-AGP-specific cDNA probe, or in the amount of translatable alpha 1-AGP mRNA. The results indicate that: after a high dose of 17 alpha-ethynyloestradiol and after acute inflammation, the increase of the alpha 1-AGP serum concentration is due to an accumulation of the alpha 1-AGP mRNA; different mechanisms and/or pathways are probably involved in regulating the synthesis of alpha 1-AGP under various stimuli; 17 alpha-ethynyloestradiol as well as acute inflammation seem to control the glycosylation process of alpha 1-AGP in an identical manner.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-193510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-291033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-4119677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-417739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-4178107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-4850204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-489712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-5006482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-6169718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-6174370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-6184374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-6194014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-6575911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-7004858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-7126780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-7192555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-7225409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-7275972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-73185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-7400146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-7470070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-823012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-83096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3977855-986249
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
225
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
681-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3977855-Animals,
pubmed-meshheading:3977855-Ethinyl Estradiol,
pubmed-meshheading:3977855-Immunoelectrophoresis,
pubmed-meshheading:3977855-Inflammation,
pubmed-meshheading:3977855-Kinetics,
pubmed-meshheading:3977855-Liver,
pubmed-meshheading:3977855-Male,
pubmed-meshheading:3977855-Orosomucoid,
pubmed-meshheading:3977855-Protein Biosynthesis,
pubmed-meshheading:3977855-RNA, Messenger,
pubmed-meshheading:3977855-Rats,
pubmed-meshheading:3977855-Rats, Inbred Strains
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pubmed:year |
1985
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pubmed:articleTitle |
The effects of 17 alpha-ethynyloestradiol and of acute inflammation on the plasma concentration of rat alpha 1-acid glycoprotein and on the induction of its hepatic mRNA.
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pubmed:publicationType |
Journal Article
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