| pubmed-article:3935769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3935769 | lifeskim:mentions | umls-concept:C0524504 | lld:lifeskim |
| pubmed-article:3935769 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:3935769 | lifeskim:mentions | umls-concept:C0001492 | lld:lifeskim |
| pubmed-article:3935769 | lifeskim:mentions | umls-concept:C0016601 | lld:lifeskim |
| pubmed-article:3935769 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:3935769 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:3935769 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3935769 | pubmed:dateCreated | 1986-1-31 | lld:pubmed |
| pubmed-article:3935769 | pubmed:abstractText | The Drosophila memory mutant rutabaga (rut) has been previously shown to have a defective subpopulation (or functional state) of the enzyme adenylate cyclase. We report here that the reduced adenylate cyclase activity is also associated with a defective responsiveness of the enzyme to forskolin. Forskolin activation isotherms of the enzyme in normal membranes reveal low- and high-affinity forskolin-interacting components; the residual enzyme in the mutant shows a smaller proportion of the high-affinity response. In addition, in mutant membrane preparations, forskolin fails to shift the Km of the enzyme for free Mg2+ and for MgATP, in contrast to the situation in the normal tissue. The defect in the responsiveness to forskolin in rut is even more pronounced in a Lubrol-solubilized enzyme preparation, and is due to intrinsic properties of the cyclase system rather than to the absence (or presence) of a soluble, or detergent solubilized, factor in rut. The reduced forskolin responsiveness maps to the X chromosomal segment 12F5-6 to 13A1-5, within the region previously reported to span the locus that controls both the abortive memory and the lack of Ca2+-stimulation of adenylate cyclase in rut17. The possible relevance of the findings to postulated molecular mechanisms of short-term memory formation is discussed. | lld:pubmed |
| pubmed-article:3935769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3935769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3935769 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3935769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3935769 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3935769 | pubmed:issn | 0167-7063 | lld:pubmed |
| pubmed-article:3935769 | pubmed:author | pubmed-author:SegalDD | lld:pubmed |
| pubmed-article:3935769 | pubmed:author | pubmed-author:DudaiYY | lld:pubmed |
| pubmed-article:3935769 | pubmed:author | pubmed-author:YovellYY | lld:pubmed |
| pubmed-article:3935769 | pubmed:author | pubmed-author:SherBB | lld:pubmed |
| pubmed-article:3935769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3935769 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:3935769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3935769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3935769 | pubmed:pagination | 365-80 | lld:pubmed |
| pubmed-article:3935769 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3935769 | pubmed:meshHeading | pubmed-meshheading:3935769-... | lld:pubmed |
| pubmed-article:3935769 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3935769 | pubmed:articleTitle | Defective responsiveness of adenylate cyclase to forskolin in the Drosophila memory mutant rutabaga. | lld:pubmed |
| pubmed-article:3935769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3935769 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:32406 | entrezgene:pubmed | pubmed-article:3935769 | lld:entrezgene |
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