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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1985-8-21
|
| pubmed:abstractText |
Ventilatory kinetics during exercise (30 W for 6 min) were studied in 3 asthmatics, 14 patients with chronic airway obstruction (11 with bronchial or type B disease, 3 with emphysematous or type A disease), and in 5 normal age-matched controls. The measure of ventilatory increase during early exercise, alpha 1-3%, was calculated as (avg minute ventilation over 1st-3rd min of exercise--resting minute ventilation)/(avg minute ventilation over 4th-6th min of exercise--resting minute ventilation) X 100. Arterial pH, PO2, and PCO2 (PaCO2) were measured in vitro at rest and within 20 s of termination of exercise. Respiratory PaCO2 oscillations had previously been monitored at rest in the patients (indirectly as in vivo arterial pH, using a fast-response pH electrode) and quantified by upslope (delta PaCO2/delta t). alpha 1-3% was normal in asthmatics (whose respiratory oscillations as a group showed least attenuation) and in type A patients (whose respiratory oscillations as a group were most attenuated). In type B patients reduction in alpha 1-3% correlated with attenuation of delta PaCO2/delta t (r = 0.75; P less than 0.01). There was no significant correlation between delta PaCO2/delta t and change of in vitro PaCO2 from rest to the immediate postexercise period. These findings are consistent with the hypothesis that attenuation of delta PaCO2/delta t slows ventilatory kinetics during exercise in type B but not type A patients. Intact respiratory oscillations are not necessary for CO2 homeostasis after the first few minutes of exercise.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1942-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3924885-Aged,
pubmed-meshheading:3924885-Asthma,
pubmed-meshheading:3924885-Carbon Dioxide,
pubmed-meshheading:3924885-Female,
pubmed-meshheading:3924885-Humans,
pubmed-meshheading:3924885-Hydrogen-Ion Concentration,
pubmed-meshheading:3924885-Kinetics,
pubmed-meshheading:3924885-Lung Diseases, Obstructive,
pubmed-meshheading:3924885-Male,
pubmed-meshheading:3924885-Middle Aged,
pubmed-meshheading:3924885-Physical Exertion,
pubmed-meshheading:3924885-Pulmonary Gas Exchange,
pubmed-meshheading:3924885-Ventilation-Perfusion Ratio
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Ventilatory changes during exercise and arterial PCO2 oscillations in chronic airway obstruction patients.
|
| pubmed:publicationType |
Journal Article
|