| pubmed-article:3875604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3875604 | lifeskim:mentions | umls-concept:C0279516 | lld:lifeskim |
| pubmed-article:3875604 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3875604 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:3875604 | lifeskim:mentions | umls-concept:C0074153 | lld:lifeskim |
| pubmed-article:3875604 | pubmed:dateCreated | 1985-9-30 | lld:pubmed |
| pubmed-article:3875604 | pubmed:abstractText | The in-vitro activity (as measured by geometric mean MICs, mg/l) of Sch 34343 against aerobic and anaerobic bacteria was compared with that of 14 other selected beta-lactam antibiotics including aztreonam, latamoxef (moxalactam), ceftazidime and imipenem. Sch 34343 had good activity (less than 2 mg/l) against most Gram-negative aerobic bacteria whether or not they contained high levels of plasmid-mediated or chromosomally-mediated beta-lactamases. It was slightly less potent against strains of Morganella and Serratia (less than 4 mg/l) and inactive against Pseudomonas (greater than 64 mg/l). A very small inoculum effect was observed against strains containing beta-lactamases indicating stability. Unlike the third-generation cephalosporins, Sch 34343 had excellent activity (less than or equal to 0.18 mg/l) against staphylococci, comparable to that of imipenem and ampicillin. While Sch 34343 had equally good potency (0.17 mg/l) against penicillinase-positive staphylococci, it was inactive against methicillin-resistant staphylococci (greater than or equal to 35 mg/l). Sch 34343 also had good activity against streptococci. The most unusual aspect of the in-vitro activity was its activity against Bacteroides (including Bact. fragilis) and other anaerobes. Sch 34343 had mean MICs less than or equal to mg/l for all Bacteroides and Clostridium spp. tested except CI. difficile (3.4 mg/l). | lld:pubmed |
| pubmed-article:3875604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3875604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875604 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3875604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3875604 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3875604 | pubmed:issn | 0305-7453 | lld:pubmed |
| pubmed-article:3875604 | pubmed:author | pubmed-author:AdamCC | lld:pubmed |
| pubmed-article:3875604 | pubmed:author | pubmed-author:WeissWW | lld:pubmed |
| pubmed-article:3875604 | pubmed:author | pubmed-author:MillerG HGH | lld:pubmed |
| pubmed-article:3875604 | pubmed:author | pubmed-author:HartEE | lld:pubmed |
| pubmed-article:3875604 | pubmed:author | pubmed-author:LoebenbergDD | lld:pubmed |
| pubmed-article:3875604 | pubmed:author | pubmed-author:NaplesLL | lld:pubmed |
| pubmed-article:3875604 | pubmed:author | pubmed-author:SabatelliFF | lld:pubmed |
| pubmed-article:3875604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3875604 | pubmed:volume | 15 Suppl C | lld:pubmed |
| pubmed-article:3875604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3875604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3875604 | pubmed:pagination | 39-56 | lld:pubmed |
| pubmed-article:3875604 | pubmed:dateRevised | 2004-11-18 | lld:pubmed |
| pubmed-article:3875604 | pubmed:meshHeading | pubmed-meshheading:3875604-... | lld:pubmed |
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| pubmed-article:3875604 | pubmed:meshHeading | pubmed-meshheading:3875604-... | lld:pubmed |
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| pubmed-article:3875604 | pubmed:meshHeading | pubmed-meshheading:3875604-... | lld:pubmed |
| pubmed-article:3875604 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3875604 | pubmed:articleTitle | Evaluation of the in-vitro antibacterial activity of Sch 34343. | lld:pubmed |
| pubmed-article:3875604 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3875604 | lld:pubmed |
