pubmed-article:3873403 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0014457 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0205197 | lld:lifeskim |
pubmed-article:3873403 | lifeskim:mentions | umls-concept:C0116281 | lld:lifeskim |
pubmed-article:3873403 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:3873403 | pubmed:dateCreated | 1985-7-17 | lld:pubmed |
pubmed-article:3873403 | pubmed:abstractText | Guinea-pig spleen cells treated with complete Freund's adjuvant (CFA) produce eosinophil-directed chemotactic inhibitory factors (ECIF). The inhibition is selective for the response of eosinophils to delayed ECF-a, which had been isolated from 24-hr-old inflamed skin lesions induced by DNP-Ascaris extract in sensitized animals and had been confirmed as being a T lymphocyte-derived lymphokine. ECIF activity is absorbed by incubation with eosinophils, but not with macrophages or neutrophils. The cells spontaneously release ECIF; pretreatment with a protein synthesis inhibitor reduces ECIF production, indicating that protein synthesis is essential. The source of ECIF seems to be lymphocytes, probably T lymphocytes. ECIF activity is recovered in two separate fractions: one elutes near bovine serum albumin (MW 70,000) and the other near cytochrome c (MW 12,500). ECIF binds to peanut agglutinin- or Limulus polyphemus agglutinin-coupled agarose beads. Furthermore, ECIF activity is blocked when eosinophils are incubated with D-galactose or sialic acid. These results suggest that ECIF derived from T lymphocytes of CFA-treated animals modulate the delayed ECF-a-mediated tissue eosinophilia, and that terminal galactose and/or sialic acid residues are essential for ECIF activity. | lld:pubmed |
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pubmed-article:3873403 | pubmed:language | eng | lld:pubmed |
pubmed-article:3873403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3873403 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3873403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:3873403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3873403 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3873403 | pubmed:month | May | lld:pubmed |
pubmed-article:3873403 | pubmed:issn | 0019-2805 | lld:pubmed |
pubmed-article:3873403 | pubmed:author | pubmed-author:HayashiHH | lld:pubmed |
pubmed-article:3873403 | pubmed:author | pubmed-author:TashiroKK | lld:pubmed |
pubmed-article:3873403 | pubmed:author | pubmed-author:HirashimaMM | lld:pubmed |
pubmed-article:3873403 | pubmed:author | pubmed-author:SakataKK | lld:pubmed |
pubmed-article:3873403 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3873403 | pubmed:volume | 55 | lld:pubmed |
pubmed-article:3873403 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3873403 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3873403 | pubmed:pagination | 115-24 | lld:pubmed |
pubmed-article:3873403 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:3873403 | pubmed:year | 1985 | lld:pubmed |
pubmed-article:3873403 | pubmed:articleTitle | The regulation of tissue eosinophilia. III. In vitro production of eosinophil-directed chemotactic inhibitory factor by T lymphocytes of complete Freund's adjuvant-treated guinea-pigs. | lld:pubmed |
pubmed-article:3873403 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3873403 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3873403 | lld:pubmed |