Linked Life Data

3815851

Source:http://linkedlifedata.com/resource/pubmed/id/3815851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-4-10
pubmed:abstractText
The use of low levels of lead in vivo in rats has been found to inhibit dihydropteridine reductase and cause an apparent increase in tetrahydrobiopterin biosynthesis. At higher dose levels inhibition of tetrahydrobiopterin biosynthesis has been observed. At low levels the disruption of tetrahydrobiopterin metabolism has been found to give an increase in the total level of biopterin derivatives but a movement away from the fully reduced form to the oxidised species in a manner consistent with dihydropteridine reductase inhibition. Lead has been found to inhibit dihydropteridine reductase in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-8981
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The effect of lead on tetrahydrobiopterin metabolism. A possible mechanism for neurotoxicity.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't