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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1987-3-12
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pubmed:abstractText |
Alkylation of adenine (5a) or 2-amino-6-chloropurine (5b) with excess trans-1,4-dichloro-2-butene (4), effected by K2CO3 in dimethyl sulfoxide or tetra-n-butylammonium fluoride in tetrahydrofuran, led in 90-95% regioselectivity to 9-alkylpurines 6a and 6b. The title compounds 2a and 2b were obtained by refluxing intermediates 6a and 6b in 0.1 M NaOH or HCl. Adenine derivative 2a is a substrate for adenosine deaminase whereas both 2a and 2b exhibit 50% inhibition of the growth of murine leukemia L 1210 cell culture at 1 mM concentration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
437-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3806625-Adenine,
pubmed-meshheading:3806625-Adenosine,
pubmed-meshheading:3806625-Adenosine Deaminase Inhibitors,
pubmed-meshheading:3806625-Animals,
pubmed-meshheading:3806625-Antibiotics, Antineoplastic,
pubmed-meshheading:3806625-Guanine,
pubmed-meshheading:3806625-Indicators and Reagents,
pubmed-meshheading:3806625-Leukemia L1210,
pubmed-meshheading:3806625-Magnetic Resonance Spectroscopy,
pubmed-meshheading:3806625-Mass Spectrometry,
pubmed-meshheading:3806625-Mice,
pubmed-meshheading:3806625-Spectrophotometry, Ultraviolet,
pubmed-meshheading:3806625-Structure-Activity Relationship
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pubmed:year |
1987
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pubmed:articleTitle |
Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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