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pubmed-article:3783618pubmed:abstractTextWe have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.lld:pubmed
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pubmed-article:3783618pubmed:articleTitleA model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.lld:pubmed
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