| pubmed-article:3747586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0020456 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0259752 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0205253 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0439227 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C1706089 | lld:lifeskim |
| pubmed-article:3747586 | lifeskim:mentions | umls-concept:C0683607 | lld:lifeskim |
| pubmed-article:3747586 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:3747586 | pubmed:dateCreated | 1986-10-20 | lld:pubmed |
| pubmed-article:3747586 | pubmed:abstractText | This study tests the hypothesis that improved muscle salvage after prolonged ischemia (4 hours) occurs when the substrate-enriched blood cardioplegic solution is markedly hyperglycemic (greater than 400 mg/dl) and markedly hyperosmotic (greater than 400 mOsm). Thirty-five dogs underwent 4 hours of occlusion of the left anterior descending coronary artery and reperfusion during total vented bypass with substrate-enriched blood cardioplegic solution, in which the glucose concentration and osmolarity were varied in relation to one another. Spontaneous systolic shortening recovered consistently (31 +/- 6%) only when glucose was greater than 400 mg/dl and osmolarity was greater than 400 mOsm. The least recovery occurred (only one of six dogs recovering spontaneous shortening) when cardioplegic glucose was greater than 400 mg/dl and osmolarity was greater than 400 mOsm. Regional segments reperfused with our standard substrate-enriched blood cardioplegic solution had lower transmural flow rates following reperfusion (56 versus 87 ml/100 gm/min, p less than 0.05), markedly reduced mitochondrial State 3 and State 4 respiration in epicardial and endocardial muscle (p less than 0.05), and the most extensive histochemical evidence of damage (63% area of nonstaining versus area at risk, p less than 0.05). We conclude that markedly increased levels of osmolarity (greater than 400 mOsm) and glucose (greater than 400 mg/dl) improve the capacity of substrate-enriched blood cardioplegic solution to salvage myocardium after prolonged ischemia. | lld:pubmed |
| pubmed-article:3747586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3747586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3747586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3747586 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3747586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3747586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3747586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3747586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3747586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3747586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3747586 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3747586 | pubmed:issn | 0022-5223 | lld:pubmed |
| pubmed-article:3747586 | pubmed:author | pubmed-author:BuckbergG DGD | lld:pubmed |
| pubmed-article:3747586 | pubmed:author | pubmed-author:YoungHH | lld:pubmed |
| pubmed-article:3747586 | pubmed:author | pubmed-author:OkamotoFF | lld:pubmed |
| pubmed-article:3747586 | pubmed:author | pubmed-author:BugyiHH | lld:pubmed |
| pubmed-article:3747586 | pubmed:author | pubmed-author:AllenB SBS | lld:pubmed |
| pubmed-article:3747586 | pubmed:author | pubmed-author:LeafJJ | lld:pubmed |
| pubmed-article:3747586 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3747586 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:3747586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3747586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3747586 | pubmed:pagination | 583-93 | lld:pubmed |
| pubmed-article:3747586 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:3747586 | pubmed:meshHeading | pubmed-meshheading:3747586-... | lld:pubmed |
| pubmed-article:3747586 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3747586 | pubmed:articleTitle | Reperfusate composition: interaction of marked hyperglycemia and marked hyperosmolarity in allowing immediate contractile recovery after four hours of regional ischemia. | lld:pubmed |
| pubmed-article:3747586 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3747586 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3747586 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3747586 | lld:pubmed |
