Linked Life Data

3690658

Source:http://linkedlifedata.com/resource/pubmed/id/3690658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-1-29
pubmed:abstractText
The first exon of the c-myc gene has unusual properties that suggest some further role in gene regulation. It encodes a large, evolutionarily conserved leader exon that is transcribed more frequently than the remaining exons of the c-myc gene. In what follows, we provide a possible explanation for these observations. We find that the major promoter of the c-myc gene is bifunctional; that is, it supports transcription by RNA polymerases II and III (pol II and III). Both enzymes initiate in vitro transcription from the major c-myc initiation site (P2), but pol III is completely blocked near the 3' end of the first exon while pol II, though partially blocked, transcribes through this region. These superimposed transcriptional activities suggest a potential regulatory mechanism by which one polymerase system could influence the activity of another.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1001-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The c-myc gene encodes superimposed RNA polymerase II and III promoters.
pubmed:affiliation
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't