Linked Life Data

3652636

Source:http://linkedlifedata.com/resource/pubmed/id/3652636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-11-16
pubmed:abstractText
One-hundred and four patients with a diagnosis of aplastic anaemia (28) or neutropenia (76) referred to our laboratory for assessment of granulopoiesis were studied. Bone marrow myeloid progenitor cell (CFU-C) frequency was measured and in 85 patients, inhibitor studies with either in-vitro drug addition or plasma co-culture were performed. Of 28 patients with aplastic anaemia, 22 (79%) had low numbers of CFU-C, while four (14%) had numbers within the normal range and two (7%) had elevated progenitor cell frequency. In contrast, of the 76 patients with neutropenia who were studied only 29 (38%) had low CFU-C numbers, 33 (43%) had a CFU-C frequency within the normal range and 14 (18%) had elevated CFU-C numbers. Thirty-nine patients had ingested potentially myelotoxic drugs and in eight of these it was possible to demonstrate drug associated inhibition of CFU-C proliferation in vitro. The drugs most commonly associated on a historical basis with myelosuppression were chloramphenicol, antimalarials, sulphonamides, anticonvulsants and nonsteroidal anti-inflammatory agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0141-9854
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The CFU-C assay in patients with neutropenia and, in particular, drug associated neutropenia.
pubmed:affiliation
Kanematsu Laboratories, Royal Prince Alfred Hospital, Camperdown, Australia.
pubmed:publicationType
Journal Article, In Vitro