Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6 Pt 2
|
| pubmed:dateCreated |
1987-7-15
|
| pubmed:abstractText |
Estrogen administration produces blood volume expansion and interstitial fluid retention. We decided to study the effect of estrogen withdrawal on blood volume and determine whether oophorectomy has an effect on lymph flow or protein concentration. The rate of left thoracic duct lymph flow averaged 0.041 +/- 0.005 (SE) and 0.071 +/- 0.008 ml X min-1 X kg-1 in castrated (n = 9) and noncastrated (n = 9) female sheep, respectively (P = 0.006). After three serial intravenous infusions of Ringer lactate solution (2% body wt/infusion) the thoracic duct lymph flow in the castrated animals increased 358, 457, and 498% over the base-line rate, compared with increase of 200, 235, and 353% in the nonpregnant ewes. However, with the lower control values in the castrated animals, the lymph flow rate reached the same absolute values as those seen in the noncastrated ewes. Lymph protein concentration and the lymph-to-plasma protein concentration ratio, as well as arterial and venous pressures, were unaltered by oophorectomy. Base-line whole blood volumes were 58.2 +/- 1.9 (n = 9) and 64.8 +/- 2.6 ml/kg (n = 9) in the castrated and noncastrated ewes, respectively (P less than 0.05). Systemic vascular compliance averaged 4.5 +/- 0.7 and 7.1 +/- 1.7 ml X kg-1 X mmHg-1 in the castrated and noncastrated ewes, respectively (P less than 0.05), whereas interstitial fluid compliance values were 12 and 32 ml X kg-1 X mmHg-1, respectively. The capillary filtration coefficients were not different in the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
252
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
R1114-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3591982-Animals,
pubmed-meshheading:3591982-Blood Proteins,
pubmed-meshheading:3591982-Blood Volume,
pubmed-meshheading:3591982-Capillary Permeability,
pubmed-meshheading:3591982-Estrogens,
pubmed-meshheading:3591982-Isotonic Solutions,
pubmed-meshheading:3591982-Lymphatic System,
pubmed-meshheading:3591982-Ovariectomy,
pubmed-meshheading:3591982-Sheep
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Lymphatic and vascular responses to fluid infusion in castrated and noncastrated sheep.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|