| pubmed-article:3576973 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C0027984 | lld:lifeskim |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:3576973 | lifeskim:mentions | umls-concept:C1520022 | lld:lifeskim |
| pubmed-article:3576973 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3576973 | pubmed:dateCreated | 1987-5-26 | lld:pubmed |
| pubmed-article:3576973 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3576973 | pubmed:abstractText | The nucleotide sequence of the mRNA encoding the fusion (F0) protein of a virulent strain of Newcastle disease virus was determined. A single open reading frame in the sequence encodes a protein of 553 amino acids with a calculated molecular weight of 59058. The amino acid sequence predicted several structural features involving the fusion-inducing hydrophobic stretch (residues 117-142) and the cleavage-activation site (residues 112-116) to generate the disulfide-linked F1 and F2 subunits. The cleavage-activation site as well as a part of the fusion-inducing sequence were compared among a series of virulent and avirulent strains by the chain-termination method using a synthetic oligonucleotide primer. It was found that without exception, the cleavage-activation site of virulent strains consisted of two dibasic residues with an intervening glutamine, Arg-Arg-Gln-Arg-Arg, whereas the corresponding region of avirulent strains was made of a sequence with single basic residues scattered among uncharged residues, Gly-LysArg-Gln-GlySer-Arg. On the basis of these observations and the previous results showing a strict correlation between the pathogenicity and the cleavability of the fusion protein of NDV (Y. Nagai, H-D. Klenk, and R. Rott, Virology, 72, 494-508, 1976), we propose the importance of the dibasic residues for efficient proteolytic activation of the fusion protein and for the pantropic property of NDV. Some strains were found to have Leu-Ile-Gly as the N-terminus of F1, whereas others contained Phe-Ile-Gly, indicating that Phe-X-Gly is not always conserved at F1 N-terminus of paramyxovirus. | lld:pubmed |
| pubmed-article:3576973 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3576973 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3576973 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3576973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3576973 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3576973 | pubmed:month | May | lld:pubmed |
| pubmed-article:3576973 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:3576973 | pubmed:author | pubmed-author:ImaiKK | lld:pubmed |
| pubmed-article:3576973 | pubmed:author | pubmed-author:NagaiYY | lld:pubmed |
| pubmed-article:3576973 | pubmed:author | pubmed-author:HamaguchiMM | lld:pubmed |
| pubmed-article:3576973 | pubmed:author | pubmed-author:ToyodaTT | lld:pubmed |
| pubmed-article:3576973 | pubmed:author | pubmed-author:SakaguchiTT | lld:pubmed |
| pubmed-article:3576973 | pubmed:author | pubmed-author:GotohBB | lld:pubmed |
| pubmed-article:3576973 | pubmed:author | pubmed-author:InocencioN... | lld:pubmed |
| pubmed-article:3576973 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3576973 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:3576973 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3576973 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3576973 | pubmed:pagination | 242-7 | lld:pubmed |
| pubmed-article:3576973 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3576973 | pubmed:meshHeading | pubmed-meshheading:3576973-... | lld:pubmed |
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| pubmed-article:3576973 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3576973 | pubmed:articleTitle | Structural comparison of the cleavage-activation site of the fusion glycoprotein between virulent and avirulent strains of Newcastle disease virus. | lld:pubmed |
| pubmed-article:3576973 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3576973 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3576973 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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