| pubmed-article:3572815 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3572815 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:3572815 | lifeskim:mentions | umls-concept:C1622418 | lld:lifeskim |
| pubmed-article:3572815 | lifeskim:mentions | umls-concept:C1882857 | lld:lifeskim |
| pubmed-article:3572815 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:3572815 | lifeskim:mentions | umls-concept:C0007732 | lld:lifeskim |
| pubmed-article:3572815 | lifeskim:mentions | umls-concept:C0060400 | lld:lifeskim |
| pubmed-article:3572815 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3572815 | pubmed:dateCreated | 1987-6-12 | lld:pubmed |
| pubmed-article:3572815 | pubmed:abstractText | The characteristics of the transport of cefixime, a new p.o. cephalosporin, antibiotic, were studied by using brush-border membrane vesicles from the rat small intestine. The initial rate of uptake of cefixime was not affected by the presence of an inward gradient of either Na+ or other monovalent cations. With an intravesicular pHi of 7.5, optimal cefixime uptake occurred at an extravesicular pHo of 5.0, with about 6-fold acceleration compared with that in the absence of an inward proton gradient (pHi = pHo = 7.5). A protonophore, carbonyl-cyanide-4-trifluoromethoxy-phenylhydrazone, abolished the stimulating effect of low pHo. In the presence of a sufficient inward proton gradient (pHi = 7.5, pHo = 5.0), cefixime uptake showed an overshoot phenomenon and apparent saturation kinetics expressed by the Michaelis-Menten equation with the maximum rate of 2.67 +/- 0.06 nmol/30 sec/mg of protein and a Michaelis constant of 0.83 +/- 0.04 mM. Cefixime uptake was inhibited competitively by glycyl-L-proline and stimulated by the countertransport effect of this dipeptide. The other peptides also inhibited cefixime uptake significantly. A valinomycin-induced inside-negative K+-diffusion potential had a dramatic reducing effect on the uptake of dianionic cefixime. All the data obtained in this study demonstrate that cefixime transport across the brush-border membrane vesicles is carrier-mediated, independent of Na+ and dependent on a H+ gradient via the peptide transport systems. | lld:pubmed |
| pubmed-article:3572815 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3572815 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3572815 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3572815 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3572815 | pubmed:month | May | lld:pubmed |
| pubmed-article:3572815 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:3572815 | pubmed:author | pubmed-author:TsujiAA | lld:pubmed |
| pubmed-article:3572815 | pubmed:author | pubmed-author:TerasakiTT | lld:pubmed |
| pubmed-article:3572815 | pubmed:author | pubmed-author:TamasSS | lld:pubmed |
| pubmed-article:3572815 | pubmed:author | pubmed-author:HirookaHH | lld:pubmed |
| pubmed-article:3572815 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3572815 | pubmed:volume | 241 | lld:pubmed |
| pubmed-article:3572815 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3572815 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3572815 | pubmed:pagination | 594-601 | lld:pubmed |
| pubmed-article:3572815 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3572815 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3572815 | pubmed:articleTitle | H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. | lld:pubmed |
| pubmed-article:3572815 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3572815 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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