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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1987-2-6
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated cDNA clones of the human c-myb mRNA that contain approximately 3.4 kilobases of the approximately 3.8-kilobase mRNA sequence. Nucleotide sequence analysis shows that the c-myb mRNA contains an open reading frame of 1920 nucleotides, which could encode a 72-kDa protein. The cDNA nucleotide sequence and the predicted amino acid sequence of the c-myb protein are highly homologous to the corresponding chicken and mouse proteins. In particular, a region toward the NH2 terminus of the protein containing a 3-fold tandem repeat of 51 residues is evolutionarily conserved and is the only region of homology with the Drosophila c-myb protein. This region may represent a functionally important structure, most likely the DNA-binding domain. cDNA clones have been used to isolate genomic clones and to define a preliminary intron/exon organization of the c-myb gene. Identification of 5' and 3' coding and noncoding exons indicates that the human c-myb locus spans a 40-kilobase region.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-14582157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-172289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-226888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-2990730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-2998780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3000623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3010282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3014652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3023843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3530745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3753748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3921261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-3941898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6093260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6159639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6194989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6198073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6254063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6275098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6278412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6289315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6304685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6305504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6324165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6327074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6585957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6589609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6687762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6694911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6866112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-6954533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-7099970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540945-719759
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9636-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3540945-Amino Acid Sequence,
pubmed-meshheading:3540945-Base Sequence,
pubmed-meshheading:3540945-Biological Evolution,
pubmed-meshheading:3540945-Chromosomes, Human, Pair 6,
pubmed-meshheading:3540945-Cloning, Molecular,
pubmed-meshheading:3540945-DNA,
pubmed-meshheading:3540945-Exons,
pubmed-meshheading:3540945-Genes,
pubmed-meshheading:3540945-Humans,
pubmed-meshheading:3540945-Proto-Oncogene Proteins,
pubmed-meshheading:3540945-Proto-Oncogenes
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pubmed:year |
1986
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pubmed:articleTitle |
Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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