Linked Life Data

3539464

Source:http://linkedlifedata.com/resource/pubmed/id/3539464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-1-30
pubmed:abstractText
This study has evaluated insulin resistance under steady-state conditions using the glucose clamp technique. Euglycaemic clamp investigations were conducted at 4-5 different insulin levels (70-1600 mUl-1) in five malnourished cancer patients, four well-nourished Intensive Care Unit patients (ICU) and 11 well-nourished individuals. Whole body uptake of glucose was measured. In three cancer patients the flux of glucose across the leg was measured. Cancer patients had significantly reduced fasting insulin concentrations, while ICU patients had increased levels compared to controls. The fasting levels of glucose did not differ among the groups. Both insulin sensitivity and responsiveness were reduced by 50% in cancer and ICU patients. At insulin levels of 200-250 mUl-1, approximately 80% of the whole body glucose uptake could be accounted for by the peripheral tissues. This study confirms that insulin resistance is a significant metabolic alteration in cancer associated malnutrition. The results demonstrate both decreased insulin sensitivity and responsiveness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0144-5979
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
539-47
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Mechanisms of insulin resistance in cancer associated malnutrition.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't