Linked Life Data

3485054

Source:http://linkedlifedata.com/resource/pubmed/id/3485054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-3-31
pubmed:abstractText
In order to assess the potential role of protease inhibitors in airways regulation in asthma, we have studied the effects of para-aminomethylbenzoic acid (PAMBA) in 74 patients with various forms of bronchial asthma. The effects were assessed in challenge tests by changes in PEF or FEV1 following oral administration of analgesics, exercise or allergen inhalation. PAMBA was used in a single blind manner with lactose as placebo. PAMBA administered orally (1.0 g) was found to reduce significantly the maximal change in FEV1, PEF following challenge in patients with analgesic-induced asthma (n = 30; p less than or equal to 0.01), exercise-induced asthma (n = 37; p less than or equal to 0.01) or allergen-induced asthma (n = 7; p less than or equal to 0.05). We suggest that PAMBA reduces the accumulation of bronchoconstrictory metabolites of arachidonic acid via inhibition of phospholipase A2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0106-4339
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-34
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Protease inhibitor prevents bronchoconstriction in man.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial