Linked Life Data

3376052

Source:http://linkedlifedata.com/resource/pubmed/id/3376052

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-7-14
pubmed:abstractText
Analysis of linkage disequilibrium D among restriction sites or bases in DNA sequences, arising from mutations in finite populations, depends on a knowledge of the variance-covariance structure of measures such as D2 between different pairs of sites. This requires evaluation of the eighth moments of gene frequencies among two, three, and four loci, and the necessary methodology is derived here and results are computed. While primary emphasis is placed on disequilibrium arising from mutation or gene conversion, the methodology also allows for the joint effects of only drift and recombination. Numerical results confirm that squared linkage disequilibria can have high variances and covariances.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0040-5809
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
54-78
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Variances and covariances of squared linkage disequilibria in finite populations.
pubmed:affiliation
Department of Genetics, University of Edinburgh, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.