Linked Life Data

3346556

Source:http://linkedlifedata.com/resource/pubmed/id/3346556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-4-13
pubmed:abstractText
Descriptions of actinically damaged human dermis have focused on the late stages of elastotic degeneration. This has diverted attention from preceding events, which are important for understanding the sequence of pathologic changes that culminate in the deranged fibrous structures of elastotic dermis. We studied specimens from the back of the necks (exposed) and inner arms (unexposed) of 24 individuals, aged 35-84 yr, by light and transmission electron microscopy. Intense sunlight exposure was common to all. A previously undescribed finding was the presence of a perivenular, histiocytic-lymphocytic infiltrate in which numerous mast cells, often in close apposition to fibroblasts, were observed. We have termed this "chronic heliodermatitis." We postulate that mast cell-derived mediators in conjunction with enzymes released by the infiltrating cells lead to breakdown of elastic and collagen fibers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-30
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Chronic heliodermatitis: a morphologic evaluation of chronic actinic dermal damage with emphasis on the role of mast cells.
pubmed:affiliation
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104.
pubmed:publicationType
Journal Article