Linked Life Data

3280241

Source:http://linkedlifedata.com/resource/pubmed/id/3280241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-5-10
pubmed:abstractText
Naturally occurring antibodies directed against the principal component of the gene are conceptually remarkable as well as of great interest to both basic and applied immunologists. In this article, some of the important literature concerning these antibodies are reviewed, concentrating on studies performed during the last 5 years. One of the major recent advances has been the generation of monoclonal anti-DNA antibodies, studies of which have shed light on the ligand-binding characteristics, idiotypic properties, and genetic origin of anti-DNA and other autoantibodies. The major current hypotheses for the origin of autoantibodies and, in particular, present evidence that anti-DNA antibodies are part of the normal immune repertoire are also discussed. Finally, the evidence that certain subgroups of anti-DNA antibodies may be pathogenic is examined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1040-8401
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-73
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Autoantibodies to DNA.
pubmed:affiliation
Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts.
pubmed:publicationType
Journal Article, Review