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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-2-20
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pubmed:abstractText |
A new prostaglandin E1 analogue (TFC-612) was orally given to streptozocin-diabetic rats for 4 weeks after the induction of diabetes and its effects on motor nerve conduction velocity were studied. The compound significantly prevented a decrease of the velocity but did not reverse abnormal sorbitol and myo-inositol contents of the sciatic nerve. The results suggest that TFC-612 has a potent effect on diabetic nerve dysfunction via other mechanism than the correction of sorbitol and myo-inositol metabolisms and could be a potential compound for therapy of diabetic polyneuropathy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
225-30
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3276309-Alprostadil,
pubmed-meshheading:3276309-Animals,
pubmed-meshheading:3276309-Diabetes Mellitus, Experimental,
pubmed-meshheading:3276309-Diabetic Neuropathies,
pubmed-meshheading:3276309-Inositol,
pubmed-meshheading:3276309-Insulin,
pubmed-meshheading:3276309-Male,
pubmed-meshheading:3276309-Motor Neurons,
pubmed-meshheading:3276309-Neural Conduction,
pubmed-meshheading:3276309-Prostaglandins E, Synthetic,
pubmed-meshheading:3276309-Rats,
pubmed-meshheading:3276309-Rats, Inbred Strains,
pubmed-meshheading:3276309-Sciatic Nerve,
pubmed-meshheading:3276309-Sorbitol
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pubmed:year |
1988
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pubmed:articleTitle |
A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats.
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pubmed:affiliation |
Third Department of Medicine, Shiga University of Medical Science, Japan.
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pubmed:publicationType |
Journal Article
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